Endocrine Abstracts

We report a 42-year-old female who was known to have autoimmune hypothyroidism for nearly 20 years with positive antiTPO antibodies. She was well controlled on levothyroxine including three antenatal periods when she required a slightly higher dose of 125 mcg daily. No significant past medical history and denies use of herbal/over the counter medications. In early 2017, the patient started to experience nonspecific symptoms of lethargy and tiredness. Her thyroid state was mana...

Case history: 63 year man with two trans-temporal incomplete resections of a glomus jugulare tumour (HNPGL) in 1993 and 2000 with regular surveillance scans for residual disease. Eight years later, an MRI demonstrated an incidental pituitary macroadenoma with cavernous and sphenoid sinuses invasion. The patient was asymptomatic but, his biochemistry revealed a markedly raised prolactin of 43,000 mIU/l with no other pituitary hormone deficiency. Cabergoline was commenced and th...

Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disorder characterised by ACTH resistance resulting in isolated glucocorticoid deficiency with preserved mineralocorticoid secretion. Approximately 25% of cases result from mutations in the ACTH receptor (MC2R) and 20% result from mutations in the Melanocortin 2 receptor accessory protein (MRAP). MRAP is a small single transmembrane domain protein that is specifically required for trafficking MC2R to the ce...

Introduction: Growth hormone (GH) replacement is widely used in the management of patients with adult-onset (AO) GH deficiency (GHD). In most cases, AO-GHD arises as a result of pituitary/peri-pituitary tumours and/or their treatment. The aim of this study was to examine the effect of GH replacement on growth/recurrence of non-anterior pituitary parasellar tumours.Methods: Fifty consecutive patients (21 males; mean age 45.9) with severe AO-GHD (peak seru...